ODCs

Cytoscape Web

Click node...

Hypochondroplasia

1 OMIM reference -
1 associated gene
21 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 7

Thanatophoric dysplasia type 2

2 OMIM references -
1 associated gene
36 signs/symptoms

Hypochondroplasia

Thanatophoric dysplasia type 2

FGFR3

(UniProt - OMIM)

(UniProt - OMIM)


COMMON GENES	FGFR3

Citations in the biomedical literature:

Hypochondroplasia		Thanatophoric dysplasia type 2
	Synonym(s): (no synonyms)		Synonym(s): - Cloverleaf skull - micromelic bone dysplasia - TD2 - Thanatophoric dwarfism - cloverleaf skull - Thanatophoric dwarfism type 2

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance - Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia - Intellectual deficit / mental / psychomotor retardation / learning disability - Macrocephaly / macrocrania / megalocephaly / megacephaly - Metaphyseal anomaly - Short hand / brachydactyly - Short stature / dwarfism / nanism

Hypochondroplasia		Thanatophoric dysplasia type 2
	Very frequent - Abnormal vertebral size / shape - Short foot / brachydactyly of toes - Short limbs / micromelia / brachymelia Frequent - Elbow anomalies(excluding luxation) - Femur anomaly / absence / agenesis / hypoplasia / bifurcation - Genu varum - Hyperextensible joints / articular hyperlaxity - Pelvis anomaly / Narrow / broad iliac wings / pubis abnormality Occasional - Apnea / sleep apnea - Bowed diaphysis / diaphyses / long bones - Lordosis - Osteoarthritis - Rachidian / spine canal stenosis - Scoliosis		Very frequent - Cloverleaf skull - Depressed nasal bridge - Flat face - Hypoplastic lungs / pulmonary hypoplasia / agenesis - Hypotonia - Loose skin / skin relaxation / excess skin / creases - Narrow rib cage / thorax - Platyspondyly - Respiratory distress / dyspnea / respiratory failure / lung volume reduction - Rhizomelic micromelia - Short rib cage / thorax - Stillbirth / neonatal death Frequent - Dilated cerebral ventricles without hydrocephaly - Frontal bossing / prominent forehead - Hearing loss / hypoacusia / deafness - Increased nuchal translucency - Kyphosis - Polyhydramnios - Proptosis / exophthalmos - Seizures / epilepsy / absences / spasms / status epilepticus Occasional - Acanthosis nigricans - Agyria / micro / pachy / macrogyria / lissencephaly / gyration / neuronal migration defect - Atrial septal defect / interauricular communication - Encephalocele / exencephaly - Holoprosencephaly / arhinencephaly / unique lateral ventricle - Hydrocephaly - Patent ductus arteriosus - Renal / kidney anomalies - Restricted joint mobility / joint stiffness / ankylosis